Cadillac continued the Escalade for this year with little change. It added only automatic climate control and powered backrest recliner. As well, it gave buyers the option of a rear liftgate/tailgate or full center-opening doors. Interestingly, redesigned Chevrolet Tahoes and GMC Yukons were given new platforms, styling, and engines. Cadillac sold every Escalade it could build and dealerships were hard-pressed to keep them in stock.

Standard equipment included full-time four-wheel drive, a two-speed transfer case, limited-slip differential, antilock braking, daytime running lights, automatic climate control, and rear air-conditioner controls. Escalades were fitted with leather upholstery, cruise control, 10-way power front bucket seats, heated front/rear seats, a Bose cassette/CD player, and a six-disc CD changer. No Escalades were offered for 2001, but a new version debuted as a 2002 model.